MaxClients setting so that your server does not spawn so many children it starts swapping.
HostnameLookups defaulted to On. This adds latency to every request because it requires a DNS lookup to complete before the request is finished. In Apache 1.3 this setting defaults to Off. However (1.3 or later), if you use any allow from domain or deny from domain directives then you will pay for a double reverse DNS lookup (a reverse, followed by a forward to make sure that the reverse is not being spoofed). So for the highest performance avoid using these directives (it's fine to use IP addresses rather than domain names).
Options FollowSymLinks, or you do have an Options SymLinksIfOwnerMatch Apache will have to issue extra system calls to check up on symlinks.
AllowOverride None everywhere in your filesystem.
MinSpareServers, MaxSpareServers, and StartServers settings all had drastic effects on benchmark results. In particular, Apache required a "ramp-up" period in order to reach a number of children sufficient to serve the load being applied. After the initial spawning of StartServers children, only one child per second would be created to satisfy the MinSpareServers setting. So a server being accessed by 100 simultaneous clients, using the default StartServers of 5 would take on the order 95 seconds to spawn enough children to handle the load. This works fine in practice on real-life servers, because they aren't restarted frequently. But does really poorly on benchmarks which might only run for ten minutes.MinSpareServers setting.MinSpareServers, MaxSpareServers and StartServers knobs. When more than 4 children are spawned per second, a message will be emitted to the ErrorLog. If you see a lot of these errors then consider tuning these settings. Use the mod_status output as a guide.MaxRequestsPerChild setting. By default this is 30, which is probably far too low unless your server is using a module such as mod_perl which causes children to have bloated memory images. If your server is serving mostly static pages then consider raising this value to something like 10000. The code is robust enough that this shouldn't be a problem. KeepAliveTimeout of 15 seconds attempts to minimize this effect. The tradeoff here is between network bandwidth and server resources. In no event should you raise this above about 60 seconds, as most of the benefits are lost.
mod_status and you also set ExtendedStatus On when building and running Apache, then on every request Apache will perform two calls to gettimeofday(2). This is all done so that the status report contains timing indications. For highest performance, set ExtendedStatus off (which is the default).
src/main/conf.h file for your architecture and look for either USE_MMAP_SCOREBOARD or USE_SHMGET_SCOREBOARD. Defining one of those two (as well as their companions HAVE_MMAP and HAVE_SHMGET respectively) enables the supplied shared memory code. If your system has another type of shared memory, edit the file src/main/http_main.c and add the hooks necessary to use it in Apache. (Send us back a patch too please.)